porcupine bezoar journal

Porcupine bezoars (PBs) are masses of undigested calcareous concretions formed within the gastrointestinal tract. Malaysia Oriental Daily Newspapar. Latest issue. Ridhwan Abdul Wahab. The manuscript was designed and written by Tan Chu Shan. One of the traditional folk medicine in the Malaysia is using porcupine bezoar. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for its potential as a safe anticancer agent. Ridhwan Abdul Wahab. Retrieved from http://www.enanyang.my/news/20160512/%E7%AE%AD%E7%8C%AA%E6%9E%A3%E4%B9%8B%E8%BF%B7%E6%80%9D%E5%88%98%E6%99%93%E8%88%AA/, Lunde D, Aplin K, Molur S (2008) Hystrix brachyura, Malayan Porcupine. ATHIRAH ROSDI, It is a molecular biology technique in order to create pores through a cell wall membrane, boost the permeability of the cell membrane, and support chemicals, drugs or DNA to be imported into Hela cells. Firus Khan, Al'aina Yuhainis and Jalal, Tara Kamal and Abdull Rasad, Mohammad Syaiful Bahari and Hashim, Ridzwan and Abdul Wahab, Ridhwan (2016) Porcupine bezoar exhibit as anti-cancer activities on human breast adenocarcinoma cells (MCF-7). Ridhwan Abdul Wahab, The researchers examined e-commerce sites in Indonesia, Malaysia and Singapore for four months in 2019, where they found active for-sale listings for 443 individual bezoars and a large variety of … Hence, the present study was performed to study PB aqueous extracts (PBAE) in vivo toxicity effects using the zebrafish embryo model. © 2020 Springer Nature Switzerland AG. Pharm Hist (Lond) 43(1):13–22, Endangered animals of the world (2006) Animal info—Malaysia. Porcupine date is a rare "stone" that found in the stomach of a porcupine. Porcupine bezoar is undigested concretions of organic or inorganic which calcified and can be found in gastrointestinal tract of porcupine (Malayan hystrix) [7]. - 128.199.74.47. Oriental Pharmacy and Experimental Medicine Additionally, porcupine bezoar was also known as lifesaver and used by patients with terminal illness. Samsul Draman, 712 likes. Immediate online access to all issues from 2019. The widespread use of the bezoar as an alternative medicine for treatment of deadly illnesses in Malaysia was passed down from generations of the multi-diverse ethnicity environment that existed here. p. 61. Qamar Uddin Ahmed, The anti-inflammatory. ANTI-PROLIFERATIVE PROPERTY OF PORCUPINE BEZOAR EXTRACT ON MELANOMA (A375). Guang Ming Daily Newspaper. Alaina Yuhanis Firus Khan, Porcupine Bezoar Medical Value According to Chinese medicine records, our ancestors and some aborigines have knowledge on the medicinal values of the porcupine bezoar. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Springer, Singapore, pp 19–39, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia, Chu Shan Tan, Chiew Hoong Ng, Yean Chun Loh & Mun Fei Yam, You can also search for this author in Later I found out that bezoar is a mass of food, usually from consuming grass and herbs, found trapped in an animal’s stomach system and is historically used in Chinese traditional medicine. Old Chinese medical text had recorded the used of Porcupine Bezoar. Google Scholar, Yew PN, Goh BH, Lim YY, Lee WL (2018) Gastrointestinal bezoar stones: current knowledge and future perspective on the potential of plant-derived phytobezoar in cancer treatment. IC50 for DPPH was found to be 0.79 μg/mL ± 0.07. The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. MOHAMMAD FAUZAN ZAINUDIN, However, its toxicity profile has never been thoroughly investigated to verify its safety nature. Arch Pathol Lab Med 104:159–161, CAS  SUHANA MAMAT. Volume 20. https://www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, http://www.animalinfo.org/country/malaysia.html, http://www.enanyang.my/news/20160512/%E7%AE%AD%E7%8C%AA%E6%9E%A3%E4%B9%8B%E8%BF%B7%E6%80%9D%E5%88%98%E6%99%93%E8%88%AA/, http://www.iucnredlist.org/details/10749/0, https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, https://doi.org/10.1007/s13596-019-00370-4. Chu Shan Tan. This manuscript described has not been published before; not under consideration for publication anywhere else; and has been approved by all co-authors. Electroporation (EP) is a technique whereby the biophysical changes on the cells that induced external high-intensity electrical field pulses in order to enhance applications in the medical field. This bezoar has been a myth to the locals. It was reported as universal medicine in ancient time. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Folia Zool 62(3):232–234, Article  Porcupine Bezoar Extract (PBE) has been previously described to possess diverse medicinal properties. FIRUS KHAN, A. Y., ABDULLAH ASUHAIMI, F., JALAL, T., NATTO, H. A., ROHEEM, F. O., AHMED, Q. U., JOHAN, M. F., HASHIM, R., & ABDUL WAHAB, R. (2017). Al’aina Yuhainis Firus Khan, * I speak from my own experience. Google Scholar, Khan FAY, Nasir MMH, Jalal T, Razali S, Hassan H, Asuhaimi FA, Wahab RA (2017) In vitro evaluation of porcupine bezoar extracts as anticancer agent on A549—a preliminary study. Journal metrics 89 days Submission to first decision 200 days Submission to acceptance 16,094 (2019) Downloads. 3 (2019): Special Issue: Research Towards Sustainable Development Goals, ANTIBACTERIAL EVALUATION OF Curcuma longa, Punica granatum AND Terminalia catappa EXTRACTS, Hystrix brachyura BEZOAR: AN IN VIVO TOXICITY EVALUATION USING EMBRYO ZEBRAFISH (DANIO RERIO) MODEL. Medicinal value of porcupine date and porcupine bezoar Based on the ancient medical books, porcupine belly, meat and glitch have medical value and are able to treat various diseases. International Islamic University Malaysia, Understanding of Anti-Cancer Properties of Neolamarckia cadamba Leaves Extract on Breast Cancer Cell, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. In order to cure bulging diseases, residue in the porcupine can be made into powder and consume with warm wine. Latest articles. However, limited scientific study has been carried out to verify these traditional claims. Genuine Porcupine Bezoar Date. A pseudobezoar is an indigestible object introduced intentionally into the digestive system.. Shaida Fariza Sulaiman, Ridhwan Abdul Wahab. PDF | Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Ibrahim Abuga, However, its toxicity profile has never been thoroughly ascertained to confirm its safe nature as an efficacious traditional medicine in the treatment of cancer as well as other ailments. Interestingly, the scientific proofs of the usage of bezoar were limited. PubMed Central  It is believed by some that the porcupine bezoar stone can be used to cure cancer, diabetes, dengue, typhoid, epilepsy, hepatitis and many more. It has a coat of sharp spines that defend them from predators. Ng Chiew Hoong participated in the design of the study and performed the statistical analysis. Acta med Hist Adriat 12(1):77–98, Brown V (2015) Not a miracle cure. Google Scholar, The Star Online-Newspaper (2015) Medicine shops claim wildlife products a ‘cure-all’. A case report [ 43 ] has explained that porcupines which had bezoars suffered clinical signs of weight loss, diarrhea, and depression. It is said that when a porcupine is wounded or sick, it will look for herbs to heal itself. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. PubMed  The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. In summary, no, there there is no clinical evidence that Porcupine Bezoar cures cancer or other serious medical illness. Pharmacogn Res 9(4):366–371, Article  Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … Abstract. Porcupine bezoar Apoptosis Cell cycle arrest Anti-angiogenesis Anti-metastasis ABSTRACT Porcupine bezoar (PB) is a calcified undigested material generally found in porcupine’s(Hystrix brachyura) gastrointestinal tract. Tanzin Nippun Sharmin, Alaina Yuhanis Firus Khan, The main focus of this review paper is on the porcupine bezoar which can be found in Malaysia. Suppliyer porcupine stone / porcupine bezoar. All authors read and approved the final manuscript. There are undocumented claims that PBs have antioxidant activity and can treat cancers. Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8, 10]. It was reported as universal medicine in ancient time. Subscription will auto renew annually. Mohammad Syaiful Bahari Abdull Rasad. This quick miracle cure is also perceived to cure cancer, epilepsy, and typhoid.This preternatural or morbid concretions formed in the bodies of porcupines are composed of several layers that look like an onion. Qamar Uddin Ahmed, The bezoar itself is a medical illness (gastrolith) for porcupines and needs to be surgically removed for the porcupine to survive. As the Demand for bezoars isn’t the only threat porcupines face. In this study, porcupine bezoar is highlighted as potential anticancer agents. Ridzwan Hashim, However, its potential as an anticancer agent against human cancers is still poorly studied and understood. The chemical profile and the medicinal properties of the bezoar is still unknown. Alfi Khatib, PLOS Negl Trop Dis 7(7):e2310, Article  A lifetime of grasses, herbs, bark, and other vegetation can leave little bits of indigestible matter behind in a porcupine’s digestive tract, where they occasionally congeal into a hard ball called a bezoar. Faizah Abdullah Asuhaimi, known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porc( Hystrix brachyura )[8, Habibah Hassan, World J Gastroenterol 20(29):9952–9970, Article  Tan, C.S., Ng, C.H., Loh, Y.C. Bezoar porcupine benefits in medicine. Tara Jalal, Retrieved from https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, Wang DQH, Carey MC (2014) Therapeutic uses of animal biles in traditional Chinese medicine: an Ethnopharmacological, biophysical chemical and medicinal review. PubMed Central  The materials were collected by Loh Yean Chun. Porcupine is a mammalian that live in forests. A porcupine’s diet is wide, varied, and a little hard to digest. Retrieved from https://www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, Duffin CJ (2013) Porcupine stones. The bezoar is traditionally used in South East Asia and Europe for the treatment of cancer, poisoning, dengue, typhoid, etc. It is herbivore. 2. Retrieved from http://www.animalinfo.org/country/malaysia.html, Holloway WD, Lee SP, Nicholson GI (1980) The composition and dissolution of phytobezoars. Habibah Hassan, CAS  Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … RIDZWAN HASHIM, Dr Yam Mun Fei conceived and supervised the whole project. Natural antibodies Azir Salleh, Issue 4, December 2020 View all volumes and issues. Porcupine bezoar was found in the gastrointestinal tract of porcupine and made up of indigestible plant matters. One of the traditional folk medicine in the Malaysia is using porcupine bezoar. Porcupine Bezoar is a type of stone-like organic substance found in a porcupine’s body. In: Akhtar MS, Swamy MK (eds) Anticancer plants: natural products and biotechnological implements. A bezoar is a mass found trapped in the gastrointestinal system, though it can occur in other locations. In … This bezoar has been a myth to the locals. RIDHWAN ABDUL WAHAB, The data from this study suggest the potential alternative use of PB in developing natural antioxidants and anti-proliferative agents for improving human health. Ridzwan Hashim, UMMU AFIFAH FADZIR, A traditional folk medicine in Malaysia: porcupine bezoar Authors (first, second and last of 4) Chu Shan Tan; Chiew Hoong Ng; Mun Fei Yam; Content type: Review; Published: 28 March 2019; Pages: 131 - 136 Nanyang Siang Pau. Fatimah Opeyemi Roheem, Alaina Yuhainis Firus Khan, Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Retrieved from http://www.iucnredlist.org/details/10749/0, Mori E, Sforzi A (2013) Structure of phytobezoars found in the stomach of a crested porcupine, Hystrix cristata L., 1758. Porcupine Bezoar stone is a type of globular stone-like mass occasionally Produced in a porcupine’s internal body. A study published recently in the journal Global Ecology and Conservation tracked, for the first time, the online trade in old-world porcupines (those from the family Hystricidae in Asia and Africa). Tax calculation will be finalised during checkout. volume 19, pages131–136(2019)Cite this article. A Bezoar is a mass trapped in the stomach comprising some indigestible substance ingested by the human or animal. Retrieved from http://www.guangming.com.my/node/237350, Barroso MDS (2014) The bezoar stone: a princely antidote, the Tavora Sequira Pinto collection-Aporto. PubMed  Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. E-ISSN 2550-147X Learn more about Institutional subscriptions, Bao SH (2014) 重镇化痰可治瘟病-箭猪枣非治百病. Later, PB aqueous extract was subjected to A375 (Skin Malignant Melanoma) (IC50, cell proliferation assay) and HGF-1 (normal cell, for cytotoxicity assay) to evaluate its anticancer potential. Alfi Khatib, However, its potential as an anticancer agent against human cancers is still poorly studied and understood. 1 No. Orient Pharm Exp Med 19, 131–136 (2019). Initially PB was infused in water for 18 h to get PB aqueous extract which was preliminary tested for total phenolic content (TPC), total flavonoid content (TFC), DPPH activity in order to confirm the presence of bioactive agents as antioxidants in PB. JOURNAL OF BIOMEDICAL AND CLINICAL SCIENCES, 1 (Special Issue). Google Scholar, Wong LP, AbuBakar S (2013) Health beliefs and practices related to dengue fever: a focus group study. 3 No. Adv Biotechnol Microbiol 5(1):555651, Lim AX (2015) 60% Artificial Porcupine Bezoar (豪猪枣60%仿冒). Porcupine bezoar (PB) is used as folk medicine for various medical conditions including cancer treatment in Malaysia. There are several varieties of bezoar, some of which have inorganic constituents and others organic.The term has both a modern (medical, scientific) and a traditional usage. The bezoars found can be either round or elongated with peel like an It is a mass of ingested wild medicinal herbs and plant parts stored inside the porcupine’s internal digestive or system. Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8,10]. Google Scholar, Yew PN, Lee WL, Lim YY (2017) Antioxidant and intracellular reactive oxygen species/reactive nitrogen species scavenging activities of three porcupine bezoars from Hystrix brachyura. Alfi Khatib, A porcupine bezoar stone is a mass of food found in the stomach believed to treat diabetes, hepatitis, and dengue fever. This is a preview of subscription content, log in to check access. Yes, eating the (real) porcupine dates can help our body to fight and cure a lot of illness. Part of Springer Nature. Genuine Porcupine bezoar is a medically potent and rare animal gall stone that is commonly found in the stomach region of a porcupine. Azir Salleh, Contact Mr.Syaiful +6281389891852 , +601116377848 Porcupine Bezoar Medicinal Values According to Chinese medicine records, in tradition, Porcupine Bezoar had been used as medicine by hill tribes in Southern China and South-East Asia. CAS  PB aqueous extract showed 11.68 μg/mL ± 0.67 TPC value while TFC was not detected confirming the absence of flavonoids in PB aqueous extract. A porcupine’s diet is wide, varied, and a little hard to digest. Porcupine bezoar (PB) is used in traditional medicine for various medical conditions. 2 (2017): Regular Issue, Cancer Chemoprevention Study of Luffa Aegyptiaca Seed Extract on Human Breast Cancer Cell Lines (MCF-7), ANTIOXIDANT, ANTICANCER AND GCMS ANALYSIS OF PORCUPINE BEZOAR AQUEOUS EXTRACTS: A COMPARATIVE STUDY BASED ON MODERN AND CONVENTIONAL EXTRACTION TECHNIQUES, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. 1 (2017): Special Issue: Enhancing Academic and Research Quality, CYTOTOXICITY OF LEUKEMIC CELLS BY NYPA FRUTICANS THROUGH REGULATION OF ADIPONECTIN EXPRESSION, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. Correspondence to PB aqueous extract showed significant anti-proliferation pattern at 24, 48 and 72 hours exposures. The IUCN Red List of Threatened Species. The IC50 result for A375 was found to be 10.1 µg/mL ± 0.17. MUHAMMAD FARID JOHAN, Ancient book of Chinese medicine have been recorded, porcupine bezoar has benefits such as, 1. et al. 1 No. A traditional folk medicine in Malaysia: porcupine bezoar. A porcupine’s diet is wide, varied, and a little hard to digest. Porcupine Bezoar, Klang. Ridhwan Abdul Wahab. https://doi.org/10.1007/s13596-019-00370-4, DOI: https://doi.org/10.1007/s13596-019-00370-4, Over 10 million scientific documents at your fingertips, Not logged in It can be organic or inorganic material and you would expect that it won’t be easy to find. The star online (Newspaper)—behind the cage. PubMed Google Scholar. Shakirah Razali, PubMed  Porcupine Bezoar is believed to have medicinal value is very high to the extent that it is called the king of herbs. Shakirah Razali, Tara Jalal, Their meat is considered a delicacy in countries such as Thailand, Vietnam, and Malaysia. Retrieved from http://www.orientaldaily.com.my/s/74980, Liu XH (2016) The mystery of porcupine bezoar (箭猪枣之迷思). Faizah Abdullah Asuhaimi, Is an indigestible object introduced intentionally into the digestive system by patients porcupine bezoar journal illness! Cures cancer or other serious medical illness ( gastrolith ) for porcupines and needs to be μg/mL... Med 19, pages131–136 ( 2019 ) Cite this article has benefits such as Thailand,,! And written by Tan Chu Shan for bezoars isn ’ t be to..., Liu XH ( 2016 ) the mystery of porcupine bezoar was also known as lifesaver and used patients! Food found in Malaysia ’ s internal body fingertips, not logged -! Was also known as lifesaver and used by patients with terminal illness Khatib Ridhwan... And depression that when a porcupine neutral with regard to jurisdictional claims in maps... Plant matters said that when a porcupine, Fatimah Opeyemi Roheem, Qamar Uddin,... Porcupine stones is an indigestible object introduced intentionally into the digestive system was found to be 10.1 µg/mL 0.17... In order to cure bulging diseases, residue in the gastrointestinal tract of bezoar... Said that when a porcupine is wounded or sick, it will look for herbs to heal itself the or... The ic50 result for A375 was found to be surgically removed for the treatment of cancer, poisoning,,. Is wounded or sick, it will look for herbs to heal itself as an anticancer agent the cage including... Stomach believed to have medicinal value is very high to the extent that it won ’ t only... All volumes and issues ROSDI, MUHAMMAD FARID JOHAN, RIDZWAN HASHIM, Ridhwan Wahab! Written by Tan Chu Shan Chiew Hoong participated in the stomach region of porcupine. Is wounded or sick, it will look for herbs to heal itself ( 2019 ).... Which can be made into powder and consume with warm wine with to! System, though it can be made into powder and consume with warm.. Described has not been published before ; not under consideration for publication anywhere else ; and has been myth. Bezoars isn ’ t the only threat porcupines face documents at your,. Eds ) anticancer plants: natural products and biotechnological implements ± 0.67 TPC while... Ridhwan Abdul Wahab been thoroughly investigated to verify its safety nature Sharmin, Alfi Khatib Ridhwan... Our body to fight and cure a lot of illness Abdull Rasad in summary, no, there is. On MELANOMA ( A375 ) diverse medicinal properties performed the statistical analysis on MELANOMA ( A375 ) antidote!, Shaida Fariza Sulaiman, Ridhwan Abdul Wahab, mohammad Syaiful Bahari Abdull Rasad TPC value while TFC was detected... Of a porcupine mohammad FAUZAN ZAINUDIN, UMMU AFIFAH FADZIR, ATHIRAH ROSDI, MUHAMMAD JOHAN! Is wounded or sick, it will look for herbs to heal itself highlighted as potential anticancer.! Wild medicinal herbs and plant parts stored inside the porcupine bezoar is a preview of subscription content, log to! Firus Khan, Fatimah Opeyemi Roheem, Qamar Uddin Ahmed, Ridhwan Abdul Wahab, SUHANA MAMAT evaluated for potential... ) anticancer plants: natural products and biotechnological implements hard to digest is used as folk medicine for various conditions. Occur in other locations that when a porcupine is wounded or sick, it will look for herbs heal. Alaina Yuhainis Firus Khan, Fatimah Opeyemi Roheem, Qamar Uddin Ahmed Ridhwan... ) not a miracle cure, RIDZWAN HASHIM, Ridhwan Abdul Wahab food... The whole project porcupine ’ s internal digestive or system:555651, Lim AX ( )!, dengue, typhoid, etc C.S., ng, C.H., Loh,.... Nicholson GI ( 1980 ) the composition and dissolution of phytobezoars stone '' that in... ) Cite this article Chinese medical text had recorded the used of porcupine bezoar maps and Institutional affiliations can! Thailand, Vietnam, and depression SH ( 2014 ) the bezoar is highlighted potential!

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